Endocrine Abstracts

Introduction: Distal and symmetrical peripheral polyneuropathy is the most frequent type of diabetic neuropathy. Its painful form (PDN) is the most common cause of non-traumatic neuropathic pain and can place a heavy burden on elderly patients’ lives. Despite the major impact that it can have on the quality of life, PDN is generally underdiagnosed because of a large interindividual variability of symptoms and in the absence of well-established diagnostic criteria.<p c...

Introduction: Metabolic syndrome (MS) is responsible for the increased cardiovascular risk in type 2 diabetics. There is a scarcity of research on the metabolic syndrome among individuals diagnosed with type 1 diabetes (T1DM). The aim of this study is to describe clinical, biochemical and therapeutic characteristics of T1DM with MS.Materials and Methods: Retrospective study including 36 patients, with T1DM and MS, hospitalized in the department of Endocr...

Background: Low medication adherence is a frequent problem in elderly individuals with chronic diseases such as diabetes. The objective is to assess the level of medication adherence and identify predictive factors for poor adherence among elderly diabetic patients.Methods: We conducted a descriptive, cross-sectional study among diabetic patients aged 65 years and older, who were attending the Endocrinology Department at Hedi Chaker University Hospital i...

Introduction: Gestational diabetes poses a significant public health challenge in Tunisia and various regions globally, affecting approximately 1 in 6 pregnant women. While it typically resolves post-delivery, about 20% of individuals with gestational diabetes (GD) develop Type 2 Diabetes (T2D) within five to ten years thereafter. Recognizing this heightened risk is crucial for prompt adoption of preventive measures. This study aimed to evaluate the perception of the risk of d...

Introduction: Non-Islet Cell Tumor Hypoglycemia (NICTH) is a rare but serious condition. We report a case of NICTH in a patient with a gastrointestinal stromal tumor.Observation: The patient was a 56-year-old with a history of metastatic gastrointestinal stromal tumor (GIST), diagnosed and operated on in 2016. He received tyrosine kinase inhibitors: Imatinib for 5 years, followed by sunitinib with two courses, and was later declared in palliative care du...

Background and Aims: Polycystic ovary syndrome (PCOS) may be the most common endocrine disorder in women of reproductive age. Most research findings suggest that PCOS is associated with eating disorders (ED). The aim of this research work is to study the eating disorders in women with PCOS.Methods: A cross-sectional study involved 172 women, 101 of them are Tunisian and 71 are French. Data collection was based on telephone interviews with Tunisian patien...

Introduction: Graves’ disease (GD) is an autoimmune disorder characterized by hyperthyroidism, and it often involves the development of Graves’ ophthalmopathy (GO). The latter occurs in a significant percentage (25-50%) of Graves’ disease cases. Active and severe ophthalmopathy can lead to a worsened prognosis and, in extreme cases, result in blindness. Reports about late ocular manifestation of GD have become scarce due to improved management.<p class="abst...

Introduction: Obesity, in its common form, exhibits extreme genetic heterogeneity, and its mode of transmission remains unknown. To investigate the impact of the genetic component, we conducted an association study between polymorphisms of functional and positional candidate genes: Leptin and its receptor gene (LEP, LEPR), Melanocortin 4 Receptor (MC4R), FTO gene: Fat mass and associated obesity, and Pro-opiomelanocortin gene (POMC); with obesity and associated phenotypes (ant...

Introduction: Differentiated papillary carcinomas (DPC) account for 0.5 to 1% of all neoplasms, and their prognosis is usually favorable. However, a local and distant recurrence is found in up to 35 % of patients. The objective of this study was to determine prognostic factors of this entity among Tunisian population.Patients and methods: We retrospectively retrieved records of 115 patients diagnosed with DTC and who were then followed at the nuclear med...

Introduction: Differentiated thyroid cancer (DTC) is one of the most prevalent malignant tumors in adolescents and young adults, accounting for 14-15 % of all neoplasms in this population. Patients present commonly with advanced-stage disease. The aim of our study was to highlight clinical and histopathological features of DTC in the adolescent population.Patients and Methods: This was a retrospective study, performed in the department of nuclear medicin...